NON-HUMAN PRIMATES IN THE PKPD EVALUATION OF BIOLOGICS: NEEDS AND OPTIONS TO REDUCE, REFINE, AND REPLACE. A BIOSAFE WHITE PAPER

Non-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White Paper

Monoclonal antibodies (mAbs) deliver great benefits to patients with chronic and/or severe diseases thanks to their strong specificity to the therapeutic target.As a result of this specificity, non-human primates (NHP) are often the only preclinical species in which therapeutic antibodies cross-react with the target.Here, we highlight the value and

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Teoria dello sviluppo economico e il caso italiano.

In this brief survey, the three Cookie most recent contributions to the discussion of growth rate differentials are considered.All three, using different arguments, arrive at the conclusion that such a disparity should be considered as exceptional.Some argue, on the one hand, that the highest growth rates have been reached thanks to a very elastic

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